Inflammation of the liver, known as hepatitis, primarily results from a viral infection. Some of its probable causes can be autoimmune hepatitis and hepatitis that takes place as a secondary outcome of toxins, drugs, medications, and alcohol. Autoimmune hepatitis happens when your body forms antibodies against your liver tissue. Hepatitis can lead to liver failure, liver cirrhosis, or even cancer.
Cannabidiol (CBD), a nonpsychoactive cannabinoid contained in the hemp plant, is stacked with various pharmacological properties and can boost liver function. It is also known to possess beneficial effects against pain, inflammation, cancer, neurological disorders, and other illnesses.
Studies have revealed the potential of CBD in treating hepatitis and alleviating the pain from liver ailments as well as the side effects of treatment.
Benefits Of CBD Oil In Hepatitis And Liver Diseases
The Endocannabinoid system with its receptors has been found to assist in the treatment of liver disease. The interaction of CBD with the endocannabinoid system can contribute to its therapeutic properties. CBD also shows anti-inflammatory, anti-ischemic, anti-oxidant, and immune-modulatory properties, which can be of use in liver diseases.
CBD Can Offer Therapeutic Activity In Viral Hepatitis
Hepatitis is characterized by liver inflammation. Viral hepatitis is among the liver’s most critical infectious diseases.
CBD has been revealed to possess therapeutic promise in viral hepatitis, particularly Hepatitis C. A study published in the Journal of Pharmacognosy Research evaluated the effect of CBD on hepatitis B and hepatitis C viruses.
The cells containing the virus were given CBD treatment following which its activity against the virus was ascertained. It was seen that CBD (on one concentration of 10 micromoles) could restrict the replication of the hepatitis C virus by almost 87%.
- CBD exhibited a dose-based inhibition of the virus with slight toxicity on the cells.
- CBD did not curb the hepatitis B virus but caused death in the infected cells transporting the hepatitis B virus.
The study also informed that:
- CBD is effective in viral as well as autoimmune hepatitis due to its effect on the CB-2 receptors.
- CBD demonstrated indirect interaction with the CB-2 receptor and causes death in immune cells (splenocytes), which consequently restricts the growth and multiplication of T cells liable for an autoimmune invasion on the liver cells. Thereby attenuation of immune reaction aids in relieving autoimmune hepatitis.
The in-vivo study mentioned that CBD showed antiviral activity against the hepatitis C virus. The researchers also deduced that CBD could be employed as a combination therapy together with available therapies for viral hepatitis.
Medication for hepatitis C can cause negative effects. The utilization of CBD as an alternative could assist in such cases.
CBD Can Secure Against Hepatic Ischemia/Reperfusion Injury
Ischemia/reperfusion damage is an extremely common injury that happens during most liver transplantations and liver surgeries.
It is accountable for deaths during transplant and graft rejections. It is marked by inflammation as a huge number of neutrophils are targeted towards the liver.
Extensive inflammation occurs due to the activation of kupffer cells, and leukocytes, existing in the liver on the entry of neutrophils and generation of pro-inflammatory mediators. Besides, oxidative and nitrative stress also arises.
CBD is believed to show powerful anti-inflammatory and anti-oxidant characteristics and so it could be helpful in mitigating the inflammatory response and avoid Ischemia/reperfusion injury.
A study evaluated the impact of CBD in mouse models of Ischemia/reperfusion injury on the basis of oxidative, inflammatory, and cell death markers. It was noticed that:
- CBD could successfully lower the inflammation, oxidative stress, and death of cells in the liver. Neutrophil infiltration was also lowered on therapy with CBD.
- There was a decrease in the concentrations of pro-inflammatory mediators like NF-kB and TNF-⍺.
- Thereby the curbing of inflammation, oxidative stress, nitrative stress, and cell death carried out by CBD could render it a handy option in avoiding Ischemia/reperfusion injury. Clear improvement in liver histology was also seen.
The same study was performed in rat models of ischemia/reperfusion liver injury. Inclusion of ischemia/reperfusion liver injury was connected with raised levels of tumor necrosis factor-⍺ and nitric oxide in the serum together with a lowering in the level of the antioxidant glutathione.
When CBD was administered to the rats, it was observed that there was considerable alleviation in liver damage linked with ischemia/reperfusion liver injury.
There was also a decrease in the levels of pro-inflammatory and oxidative species like nuclear factor-kB, cyclooxygenase-2, etc.
The study found that CBD has a potential therapeutic part to play in the stoppage and treatment of hypoxia-reoxygenation injury (ischemia/reperfusion injury).
CBD Helps In Autoimmune Disorders
The direct antiviral action of CBD against the HCV (Hepatitis C Virus) shows that this plant molecule has an impact against viral as well as non-viral hepatitis, termed autoimmune hepatitis. Autoimmune hepatitis comprises an inflammatory liver disorder caused by macrophages and activated T-cells. Studies have revealed that CBD, by communicating with the CB2 receptor, causes the death of damaged cells (apoptosis) in immune cells known as thymocytes and various cell populations called splenocytes. This restricts the multiplication of T-cells and macrophages which either invade liver cells or promote the discharge of pro-inflammatory cytokines that lead to autoimmune hepatitis within the liver. CBD receptor stimulation is believed to subdue inflammation and modulate immune reactions to viral infection.
The advantage of CBD in relieving liver fibrosis, which results from untreated viral hepatitis, was also exhibited in earlier studies. The studies displayed that among the most vital cellular events in the growth and advancement of liver fibrosis is the triggering of hepatic stellate cells (HCSs), which are liver cells that play a crucial role in liver physiology and fibrogenesis. CBD was found to create apoptosis in activated HSCs by communicating with the endoplasmic reticulum, which is a network of tubular membranes.
CBD Is A Potent Anti-inflammatory Agent
CBD exerts a direct influence on pro-inflammatory cytokines, which are small proteins secreted by specific cells of the immune system. CBD curbs inflammatory cytokines and prevents damage. This raises the resilience of the liver tissues and helps in the continuous filtering of toxins and waste from the blood.
Hepatitis is known to scar the liver which can cause liver failure and more serious ailments. The anti-inflammatory action of CBD helps to lower such scarring, thereby lessening the probability of worse ailments like liver cirrhosis or possibly cancer.
CBD has also shown promise in lessening liver damage resulting from hepatitis C infection. Applying CBD oil for treating hepatitis has multiple benefits. CBD preserves the liver from acute injury. A test performed on mice indicated the results of treating hepatitis useful CBD. The results revealed a reduction in liver injury.
Experimental research conducted by the Hadassah-Hebrew University Medical School in 2011 exhibited that intake of CBD promotes liver function in a mouse model of progressive liver disease, specifically due to its capacity to lower hepatic inflammation.
A study indicated that myeloid-derived suppressor cells (MDSCs) perform a major role in mitigating inflammation. Their stimulation helps to safeguard the liver from hepatitis. Phytocannabinoids like CBD have the potential of stimulating these cells by triggering the TRPV1 vanilloid receptors.
MDSCs stimulated by CBD were found to successfully curb the proliferation of T cells and alleviate inflammation. Thus, it can be said that CBD can play a therapeutic role in hepatitis and liver inflammation on the basis of its communication with the TRPV1 vanilloid receptors.
CBD Is An Excellent Antioxidant
Oxidation is an injurious procedure that occurs as a byproduct when the liver enzymes disintegrate the waste products present in the blood. Being a powerful antioxidant, CBD halts oxidation. Your liver absorbs molecules found in the blood and begins the degradation process which ends with the kidneys producing urine. This process generates free radicals called oxidants that can cause harm to human cells by promoting inflammation on account of their reactivity.
Taking CBD helps in disintegrating these harmful compounds that can affect the DNA strands. When CBD attaches to free radicals, it avoids any damage that can result from attaching with main cell structures. These free radicals gather near the liver thereby exercising pressure upon the hepatic cells. Cannabinoids, therefore, work as a defense between the liver and the risks posed by the byproducts.
CBD Alleviates Hepatitis C Associated Pain
A few patients affected by hepatitis C may experience abdominal pain or discomfort in the region of the liver. It might vary from a dull ache to intense, stinging pain.
This type of extensive abdominal pain is frequently hard to ease and can produce the feeling of nausea. The anti-emetic properties of CBD help to relieve nausea. Moreover, the proven analgesic and the anti-inflammatory properties of CBD can offer respite to such abdominal pain and joint pain caused by Hepatitis C infection.
The membranes surrounding the liver have plenty of pain receptors. CBD, by interacting with the pain receptors of the endocannabinoid system, can help with pain management. Through its regulation of neurotransmitters, the endocannabinoid system controls pain sensation, immune function, cognition, memory, sleep, appetite, and mood control among other bodily systems.
A review conducted by GW Pharmaceuticals in 2008 has exhibited that CBD aids in pain management and treatment by reducing inflammation and regulating the endocannabinoid system (ECS) which performs a vital part in modulating the immune system.
CBD Can Protect Against Alcohol-Induced Hepatitis
Acute alcohol consumption causes fatty liver or steatosis. Its effective prevention can safeguard the liver from advanced damage due to alcohol. A study evaluated whether cannabidiol (CBD) can work as an antioxidant and shield the liver from alcohol-triggered oxidative stress. Cannabidiol can inhibit acute alcohol-induced steatosis of the liver in mice, probably by restricting the rise in oxidative stress and the stimulation of the JNK MAPK pathway that regulates processes like cell differentiation, cell multiplication, and cell death.
The natural plant component of CBD contains antioxidant, immunomodulatory, and antiepileptic, and anxiolytic properties. Several experimental data propose that CBD can be utilized for different purposes in alcohol use disorder as well as liver and brain damage occurring from excessive alcohol consumption.
CBD has also been found to display anti-fibrosis properties by causing death in cells that release collagen and create fibrosis. It also reverts changes connected with the alcohol-induced injury.
Alcoholic hepatitis (AH) is a more serious form of ALD (Alcoholic Liver Disease). This causes fat accumulation as well as liver inflammation due to which there is scarring of the liver, also called fibrosis. If the progression of AH continues, it can lead to cirrhosis. The severity of this condition can vary from moderate to severe. Mild AH can be reversed if a person abstains from drinking, however, severe AH can lead to serious complications such as liver failure and eventual death.
CBD can safeguard against liver fibrosis and alcohol-based liver injury. Liver fibrosis is marked by the deposition of collagen within the liver during liver ailments and chronic liver damage. These include hepatitis infection and excessive use of alcohol. Fibrosis can advance into liver failure and cirrhosis.
Primary collagen-producing cells, like stimulating hepatic stellate cells and the non-parenchymal cell population of the liver called portal fibroblasts, are involved in collagen deposition within the liver.
Investigation revealed that CBD caused the death of stimulating hepatic stellate cells, which were responsible for the generation and secretion of surplus collagen, which ultimately led to liver scarring and fibrosis.
CBD displays anti-inflammatory, anti-oxidant, anti-proliferative, and analgesic properties that make it an effective remedy in combating hepatitis and at the same time, prevent the growth of cancerous cells in liver cirrhosis. By preventing scarring and fibrosis, CBD can cope with hepatitis in multifarious ways and treats the symptoms of hepatitis, and protects from liver damage and chronic liver injuries.
Further, you will wish to consume pure and high-quality CBD products free of toxins. This could be advantageous in a myriad of liver ailments and so you should purchase CBD from reliable manufacturers. You can check out ThoughtCloud Isolate CBD in Cold Pressed Hemp Seed Oil. This hemp oil includes CBD Isolate, the pure form of CBD which does not get you high and is loaded with antioxidants, apart from being anti-inflammatory and pain-relieving.
Drop us a line in the comments section on the medical regimen you are following to cope with hepatitis and how things are working for you.