Kidney Ailments denotes a condition that is long-term and is represented by impaired kidneys that have difficulty in filtering blood. Often linked with advancing age, but such a condition can impact anyone. Kidney damage results in waste accumulation inside the body that causes problems and affects the overall wellness of renal patients. Generally, harm to kidneys occurs gradually either due to elevated blood pressure or glucose level. However, kidney function can also alter due to damage or disease. Fortunately, Cannabidiol or CBD for kidney disease has proven itself to be a potential health asset.
Findings on CBD And Kidney Ailment
Research conducted on an animal in 2009 has proved that CBD can lower cell death, kidney inflammation, oxidative stress, and also revamps renal function. You can follow up the study revealing the health benefits of CBD for kidney disease.
It is a known fact that high blood pressure is also a possible factor in kidney damage, and CBD has the capacity to regulate blood pressure. Therefore, CBD can bring about the vasodilation of blood vessels which results in better blood flow and also lowers blood pressure. All of this contributes towards the lessening of renal damage.
In renal insufficiency or failure, the kidney is not able to filter properly the metabolic wastes out of the bloodstream. Chronic Kidney Disease (CKD) has links with the dysfunctioning of the endocannabinoid system or ECS. This endocannabinoid mechanism balances our various body systems such as metabolism, appetite, mood, hormonal level, nerve, and also sleep. There has been proof of ECS maladjustment in Chronic Kidney disease. Moreover, studies have also hinted that treating with AM251, a CB1 antagonist and ECS deterring agent enhances the renal results in rats that are obese.
Kidney And The Cannabinoid Receptors
CB1 functions as a primary mediator of fibrosis in the kidney which is a progressive process that affects the kidneys and results in kidney failure. Hence, CB1 plays an important function in triggering of myofibroblasts that fix injured tissues and heal wounds and may well become a field of study for the treatment of chronic kidney disease(CKD).
Moreover, ECS dysfunction is also associated with diabetic nephropathy as diabetes changes the endocannabinoid mechanism in various organs. The expression of the cannabinoid receptors CB1 and GPR55 in adjacent tubules changes as a reaction to increased glucose and albumin levels. More findings will decide the efficacy of these cannabinoid receptors as physiological objects that can treat and safeguard against diabetic nephropathy.
Role of CBD
CBD aims at curbing inflammation and this can open new therapeutic ways for treating CKD. Acting as an anti-inflammatory medium CBD also deters every inflammatory cytokines and NF-kB which constitutes a protein and functions to control cytokine production, regulate DNA transcription and cellular growth. Oxidative stress and constant swelling are factors that are linked with nuclear factor (NF-kB) stimulation and contribute to the development of chronic kidney disease (CKD).
CBD Controls The CB2 Receptors
The type 2 cannabinoid receptor (CB2) provides safeguarding influence in degenerative diseases that are incurable. Above all, the CB2 receptor has its significance in humans as well as empirical diabetic nephropathy (DN). The receptor CB2 conveys through podocytes that are situated inside the Bowman capsule of the kidneys. Moreover, in diabetes, the stimulation of CB2 improves the presence of albumin in the urine as well as protein loss in podocytes. All this reveals the protection that communicating through CB2 in the case of diabetic nephropathy gives.
CBD Blocks The TRPV1 Receptors
An increase of TRPV1 inside mononuclear cells of kidney patients who are in their last stage heightens vulnerability to NADA or N-arachidonoyl-dopamine has driven cell death. The up-regulation of the protein TRPV1 also known as the vanilloid receptor 1 which is responsible for feeling extreme heat and also pain reveals the inflammatory conditions. This up-regulation can also be a reaction to the inflammatory environment caused by CKD.
Besides, TRPV1 also works as sensors for inflammatory signals, heat, and also protons. It also provides a possible answer to the low lymphocyte count and damaged immune function in CKD sufferers. Hence, TRPV1 and probably CB2 antagonists display the capacity to treat immune dysfunction in end-stage renal disease (ESRD).
CBD Safeguards The Kidney During Damage
An analysis of the cannabidiol or CBD treatment in an animal sample with reperfusion kidney injury showed its safeguarding effect against oxidative injury and inflammation. These responses were exclusive to the stimulation of CB1 and CB2 receptors.
CBD also shields the renal tissue by hindering inflammatory and fibrosis passages that lead to renal disease.
CBD Shields Kidneys Against Toxins
Cannabidiol (CBD) lessens the nephrotoxicity brought by cisplatin, a drug used in chemotherapy, by reducing oxidative stress, cell destruction, nitrosative stress, and inflammation. Besides, it also improved renal function. Therefore, it can be hinted that cannabidiol can provide a new preservative strategy to counter nephrotoxicity induced by cisplatin.
CBD For Kidney Diseases (User Reviews)
Very satisfied with my first order which I give to my two dogs! The oldest is 18.5 years old and has kidney issues and my youngest is 3 and has anxiety issues. Would happily recommend this cbd oil!
Having been on xanax and Ambien for years it is wonderful to take something that helps me relax and doesn’t give me a hangover. I also suffer from a horrible kidney disease that at times is causes great pain. This CBD oil helps a great deal. I have cut my pain med in half.
I love this pet cbd for my senior doggy and senior kitty. They both love the taste, helps with their anxiety and helps alleviate joint paint for them both. They both get excited when the cbd bottle comes out. I also use the pet cbd to give to our doggy before we give her subq fluids to keep her calm as she was diagnosed with kidney disease about a month ago (we found out when she was in renal failure, but her levels are stable now 3 weeks later). Cbd is also safe for dogs with kidney issues as they cannot take certain pain relievers because they must be filtered thru the kidneys. We give her fluids under her skin everyday and the cbd helps to keep her calm while we administer them to where she just lays down and chills out while she gets the fluids. The cbd also works so fast to calm our pup down. My partner and I are so grateful for thoughtclouds pet cbd that helps our babes feel more comfortable and calm.
In the final, there is abundant supporting evidence to show the indirect interaction of CBD on our endocannabinoid system. CBD, in fact, acts as a primary regulator of the endocannabinoid mechanism. Since CBD is linked with dysfunction of the ECS, therefore CBD can be immensely helpful in inhibiting the development as well as the advancement of kidney diseases.
CKD is related to ECS dysfunction. CBD is a major regulator of the ECS and can well become an aid in halting the progression of kidney ailments. Above all, Cannabidiol or CBD has a vast potential in helping curb kidney failure due to its antioxidant and anti-swelling properties.