The curative benefits of CBD in numerous debilitating conditions is a feather in its cap. Moreover, the approval by FDA for Epidiolex as a prescription drug which has cannabidiol or CBD as its active component is a step ahead in cannabinoid research. This CBD based medication Epidiolex, the only FDA authorized Cannabidiol prescription is marked for seizure treatment linked with Dravet and Lennox-Gastaut syndromes. Surely, CBD for tuberous sclerosis holds great promise in treating this genetic disease.
The Rare Illness: Tuberous Sclerosis Complex (TSC)
TSC comprises a genetic ailment that generates non-cancerous tumors to develop in various portions such as the brain, kidney, heart, eyes, and lungs. Seizures, delay in growth, intellectual infirmity as well as autism are symptoms that are likely in TSC. These tumorous growth in Tuberous sclerosis are because of a mutation in the gene TSC1 or TSC2. Such growths intervene with the working of the brain in multiple ways and can also result in psychiatric issues, kidney and lung disease and also skin changes.
The flare-up in the symptoms can largely vary individually, and this neurological disorder can seriously impact the life quality of the patients. The frequent medical condition that is seen in TSC is epilepsy which involves frequent seizures. Actually, 80 – 90% of TSC sufferers, are likely to develop epilepsy at some point of their lifetime. TSC can result in various kinds of seizures like infantile convulsions, tonic-clonic seizures or particular seizure symptoms such as Lennox-Gastaut disease.
Seizures that result from TSC are normally treated with regular anticonvulsant medications. Incurably, the seizures from TSC afflicting both children as well as adults are difficult to curb with these medicines. As such, the patients are on the lookout for better alternatives.
How Can You Take CBD For TSC?
Preliminary research has supported the anti-seizure properties of the organic hemp plant-derived cannabinoids such as CBD (cannabidiol). Cannabinoids can have the capacity to lower the excessive stimulation of neurons in a seizure by adjusting the regulation of different ion channels. They can also assist in curtailing inflammation of the brain and other mechanisms.
A survey was also performed by a research team directed at the frequency, magnitude and time limit of uncontrolled convulsions in TSC patients. The investigating team also noticed the life quality of the patient, reliance on prescription drugs, and maintenance of CBD therapy for a long duration. The conclusion reached by the study revealed that sixty percent of the members experienced an almost 80-100% curtailment in their recurrence of seizures. At the same time, marked improvements were also seen in the life quality of TSC patients.
A substantive level of appetite, mood elevation, and normal cognitive skill was detected among the users of CBD treatment. In finality, the study held that CBD for tuberous sclerosis can be used for a long duration to treat the recurrence, degree and time period of a convulsive crisis being secondary to this genetic ailment called TSC.
An open-label testing was also conducted in the United States by researchers on patients afflicted with TCS. The main aim of the test was to ascertain the type of patients who would react the maximum to Cannabidiol (CBD). As CBD was acknowledged a likely antiepileptic agent within the medical circuit, therefore the researchers decided to analyze its efficacy further. They inducted around 18 patients for testing who persisted with their regular drug for anti-epilepsy. The patients along with their regular medicine were administered CBD in the dosage of 5 mg per kg daily. During the course of the trial, the CBD dosage was augmented every week until it reached 50 mg per Kg.
Here’s what occurred! The recurrence of seizures reduced on a weekly basis during the treatment year. Initially, the average rate of seizures every week within the group figured 22. Taking CBD curtailed that number to 7.7 after a year. It was also found that patients using clobazam along with CBD got favorable results. The primary adverse reactions that were noticed were drowsiness, slight daze, and diarrhea but it was reported by patients to be easily controlled after adjusting the CBD dosage. On the whole, the outcome of the scientific test yielded positive results. This will encourage future studies on the effectiveness of CBD for tuberous sclerosis and also in epilepsy.
Application Of CBD For Intractable Epilepsy
Another study conducted by Hess et al., of CBD use in intractable epilepsy sufferers, the frequency in seizure revealed a midway reduction of 48.8%. Besides, in this clinical study, almost fifty percent of patients displayed a 50% lowering in seizures. Such responses were sustained throughout the follow up for twelve months. Those who were consuming clobazam presented a response rate touching 58.3% in comparison of 33.3% by patients not consuming clobazam. These investigations hint at the scope of CBD as an anti-seizure medicine in case of intractable epilepsy caused by TSC. Moreover, certain caution should also be exercised when we correlate such results with what the patients, as well as their families, hoped for.
To know more about the use of cannabidiol in the latest therapy for epilepsy that is drug-resistant in patients suffering from tuberous sclerosis complex (TCS) you can view the following link:
Furthermore, CBD has also proved itself to be a secure and well-tolerated alternative for treating refractory epilepsy in TSC sufferers.
Overall, CBD has emerged as an alternative therapy to epilepsy treatment when various anti-epileptic drugs tend to disappoint. Moreover, CBD does not carry harmful side effects, and the only reactions generally found were drowsiness, turmoil, and diarrhea. These are hardly regarded as adverse reactions and should be viewed positively as a beneficial and easily tolerated AED to treat intractable epilepsy. The positive aspect has been of using CBD for tuberous sclerosis over a long stretch of time with no harm, while antiepileptic or steroids that are broad-spectrum get dangerous if continued for a long duration.