The synovial membrane lines the inside of different joints whose inflammation causes synovitis. Synovitis frequently results from constant joint bleeds that are not treated initially or properly. Synovitis causes the synovial membrane to thicken and develop more blood vessels, thereby increasing joint bleeding. The symptoms of synovitis may include redness, warmth, swelling, and pain with a joint motion which can cause much discomfort. The therapeutic properties of CBD offer a safe and natural alternative against these symptoms due to its analgesic, anti-inflammatory, bone healing, and cartilage forming properties.
What Constitutes Synovitis
Synovitis, an autoimmune disease signifies synovial membrane inflammation. The synovial membrane or the synovium is the joint capsule inner lining that discharges the synovial fluid. Synovium inflammation causes hypertrophy or thickness of tissue, greater vascularity or blood flow to the region, and more fluid protection, leading to joint pain, swelling, and tenderness.
Causes Of Synovitis
For an active, fit person, the most prevalent cause of synovitis includes joint overuse.
Nevertheless, synovitis also includes a common symptom of some types of inflammatory arthritis. These patients have a huge growth of the synovium as part of an unusual immune response, wherein the body misinterprets cartilage as a foreign substance that should be attacked. The absence of cartilage ultimately damages the joint surface and causes stiffness and pain common to all types of arthritis. However, osteoarthritis, the more common type of arthritis, does not include this kind of inflammatory response. Synovitis can also form part of rheumatic fever, injury, tuberculosis, or gout.
Symptoms Of Synovitis
The initial and leading symptom of synovitis is a red, warm, and swollen joint. The major symptoms of synovitis comprise:
- The joint seems inflamed and appears puffy to touch. This particularly occurs in the event of rheumatoid arthritis on account of the mass of inflammatory cells
- The joint gets warmer due to greater blood flow from inflammation
- The enzymes discharged by the cells inside the joint space causes pain and irritation
- Where this process is ongoing over the years, the enzymes slowly digest the cartilage and bone of the joint. This further leads to chronic pain and decaying changes.
How CBD Is Effective In Synovitis
Global researchers are examining the recognized anti-inflammatory qualities of CBD as a therapy for both synovitis and the resulting chronic pain. It also slows the advancement of the disease significantly.
Acts On The Endocannabinoid System
With regard to functionality, CBD for synovitis may really act by inhibiting T-cell activity in the region of joint inflammation. T-cells probably perform a vital role in the development of rheumatoid arthritis and synovitis. For any cause, molecular triggers signal for the immune (T-cell) invades wholesome synovial tissue, thus inducing the inflammation and following pain connected with synovitis.
Moreover, CBD also acts to communicate with the body’s individual endocannabinoid system or ECS. Briefly, the ECS is an extensive network of naturally present cannabinoids (similar to CBD) and cannabinoid receptors. These receptors are present all across the human body, like the synovial tissue that’s targeted and invaded by immune cells in synovitis.
If a patient applies CBD oil, the ECS receptors are activated and able to react to the influx of fresh cannabinoids (or CBD oil). When the CBD attaches to the body receptors, the substrate gets active and starts acting to control pain, reduce inflammation, and promote overall joint function.
Helps To Lower Inflammation
Though joint inflammation is common with synovitis, the severity differs based on the kind of synovitis. A study performed on the effects of CBD on microglial cells revealed that cannabinoids reduce inflammation in multiple ways:
- CBD restricts the production of cytokines
- CBD subdues STAT1, a vital element in the pro-inflammatory process
- CBD subdues a signaling pathway controlling pro-inflammatory genes and regulating the body’s reaction to infection and stress. Suppressing this pathway lowers inflammation.
- CBD hikes the activity of STAT3, which performs a part in homeostasis and anti-inflammatory processes
- CBD suppresses enzymes, raising endocannabinoid concentration
- Activates the TRPV1 receptors engaged in the inflammatory process creating analgesic and anti-inflammatory effects
- Stimulates the adenosine receptors generating anti-inflammatory effects
CBD has a useful anti-inflammatory and anti-arthritis drug as revealed in a study. Mice, immunized with type II collagen to draw chronic collagen-induced arthritis symptoms, where CBD was administered orally or by injection. The results displayed CBD to effectively obstruct the advancement of arthritis and supported clinical improvement in mice. Examining their lymph nodes revealed a considerable reduction in type II collagen. Analyzing the synovial cells of the knee showed a decrease in tumor necrosis.
It was found in a study that the synovial fluid and tissue of rheumatoid arthritis patients revealed oxidative stress damage. The powerful antioxidant properties of CBD also helped to lower oxidative stress that is an underlying cause of inflammation.
Aids To Alleviate Pain
The non-psychoactive cannabinoid CBD can also change pain perception by affecting the function of the TRPV1 receptor, commonly known as the vanilloid receptor, which identifies and regulates alterations in body temperature and generates the sensation of heat and pain. CBD attaches to these receptors, stimulating them to speed up desensitization, thereby lowering pain.
Regulates Bone Metabolism
The endocannabinoid system has been also currently involved in bone metabolism regulation. Endogenously formed cannabinoids comprise hydrophobic molecules sourced from membrane phospholipids hydrolysis. These substances, together with plant-based and synthetic cannabinoids communicate with the CB1 and CB2 cannabinoid receptors as well as the GPR55 receptor to control cellular activity through various signaling pathways. The skeletal constitution of mice with focussed cannabinoid receptors inactivation and pharmacological researches have revealed that cannabinoids perform a vital part in bone metabolism regulation.
Mice having CB1 deficiency have great maximum bone mass due to an osteoclast malfunction but acquire age-based osteoporosis due to damaged bone development and storage of bone marrow fat. Mice having CB2 deficiency have comparatively normal maximum bone mass though inherited age-based osteoporosis due to elevated bone turnover having bone resorption uncoupling from bone creation.
Mice having GPR55 inadequacy have raised bone mass due to a flaw in the osteoclast’s resorptive activity, though bone formation remains unaltered. Cannabinoids get also formed within synovial tissues, while preclinical researches have revealed that ligands of cannabinoid receptor are helpful in the therapy of inflammatory arthritis. Such data show that cannabinoid receptors with the enzymes involved in the synthesis and breakdown of ligand perform major roles in the remodeling of bone and for the pathogenesis of the joint disease.
Final Thoughts on CBD For Synovitis
Besides the direct advantages CBD has revealed within the joint when utilized topically, CBD oil consumed orally is supposed to handle chronic pain. Cannabinoids, like CBD, are believed to join themselves to CB2 receptors that play a part in the immune system by regulating pain and inflammation associated with synovitis. Studies display CBD affects the manner these receptors react to impulses from the brain, probably aiding to lower inflammation and pain. It was also discovered that CB2 receptors hamper the production of pro-inflammatory cytokines and raise anti-inflammatory cytokines, which lowers inflammation and restores harmony in the immune system. Another manner of Cannabidiol action involves retardation of T-cell production and suppressing immune system memory, implying its potential of reducing further autoimmune attacks.
Although CBD suppresses immune functions, it does not halt all immune activities and some immune cells can still be discharged. This enables people to still heal from injuries while lowering inflammation. This renders it nearly a perfect immunosuppressant!