According to researchers, cannabidiol (CBD) might be an effective therapeutic for difficult-to-treat brain cancer. Cannabidiol, or CBD, is a non-psychoactive compound derived from marijuana. The study focused on glioblastoma, a deadly form of brain cancer that develops and spreads swiftly. Despite tremendous advancements in therapy, survival rates for this malignancy have not increased considerably.
“Further research and treatment options are urgently needed for brain cancer patients,” said Chase Gross, a student in the Doctor of Veterinary Medicine/Master of Science program at Colorado State University. “Our work shows that CBD has the potential to provide an effective, synergistic glioblastoma therapy option and that it should continue to be vigorously studied.”
Findings Of Mr. Gross
Mr. Gross was supposed to discuss these findings at the annual conference of the American Society for Pharmacology and Experimental Therapeutics in San Diego. Although the meeting, which was supposed to coincide with the 2020 Experimental Biology conference, was postponed due to the COVID-19 outbreak. Hence, the abstract of the study team was published in the FASEB Journal.
Mr. Gross and colleagues compared human and canine glioblastoma cells since the cancers are similar in both species. In addition, they compared the effects of CBD Isolate and CBD extract. Both the compounds contain trace levels of other naturally occurring substances such as CBD or THC.
The current research found that CBD’s harmful effects are mediated through the cell’s natural apoptosis pathway, a type of programmed cell death. Huge, enlarged intracellular vesicles likewise characterized CBD-induced cell death before the membrane began to bulge and collapse. This was true for all of the cell lines investigated.
CBD’s anticancer activities, according to the researchers, target mitochondria—the cell’s energy-generating structures—by causing the mitochondria to malfunction and generate deadly reactive oxygen species. Their investigations revealed that CBD treatment resulted in considerable reductions in the activity of mitochondria.
Final Thoughts On CBD For Brain Cancer
“CBD has been zealously studied in cells for its anticancer properties over the last decade,” said Mr. Gross. “Our study helps complete the in vitro puzzle, allowing us to move forward in studying CBD’s effects on glioblastoma in a clinical setting using live animal models. This could lead to new treatments that would help both people and dogs that have this severe cancer.”
The researchers then intend to go from cell cultures to animal models to examine CBD’s impact on glioblastoma. If the animal experiments go well, the research might advance to clinical trials on dogs being treated at the Colorado State University Veterinary Teaching Hospital for spontaneously occurring glioblastoma.